"Auto-Immune, the viral route is confirmed", Press release by the INSERM on some of the results of the FIGHT-MG project

PDF version available here.



IDENTICAL TWINS: FIGHT-MG researchers need your help!

We are looking for identical twins, one of which or both suffering from MG, in order to participate
to a study on the implication of genetic and environmental factors in MG.
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Date of publication Title Main Author Title of the periodical or the series
03/02/2012 A new thiopurine S-methyltransferase haplotype associated with intolerance to azathioprine Colleoni L Journal of Clinical Pharmacology
02/07/2012 AMDA 2.13: A major update for automated cross-platform microarray data analysis. Kapetis D BioTechniques
20/12/2012 Antigen-specific apheresis of autoantibodies in myasthenia gravis Lazaridis K Annals of the New York Academy of Sciences
09/06/2012 Anti-MuSK- and anti-AChR-positive myasthenia gravis induced by d-penicillamine Poulas K J Neuroimmunol.
12/12/2011 Autoantibodies to Lipoprotein-Related Protein 4 in Patients With Double-Seronegative Myasthenia Gravis Zhang B Arch Neurol.
18/09/2012 Autoimmune mechanisms in myasthenia gravis Etiology of Myasthenia Gravis: innate immunity signature in pathological thymus Cavalcante, P. Current Opinion in Neurology
02/03/2011 Blocking of IL-6 suppresses experimental autoimmune myasthenia gravis R. Aricha Journal of Autoimmunity
29/08/2011 Classification of dendritic cell phenotypes from gene expression data Tuana G BMC Immunology
03/12/2012 Defects of immunoregulatory mechanisms in myasthenia gravis: role of IL-17. A. Gradolatto Annals of the New York Academy of Sciences
06/04/2010 Detection of poliovirus-infected macrophages in thymus of patients with myasthenia gravis Cavalcante P Neurology
10/10/2011 Development of a highly sensitive diagnostic assay for muscle-specific tyrosine kinase (MuSK) autoantibodies in myasthenia gravis Trakas N J Neuroimmunol.
01/08/2010 Development of novel therapies for MG: Studies in animal models Souroujon MC Autoimmunity
30/06/2011 Epstein-Barr virus persistence and reactivation in myasthenia gravis thymus Cavalcante, P. Ann Neurol
17/12/2012 Experimental MG in Aire KO mice - A link between Aire and Treg cells Aricha, R. Annals of the New York Academy of Sciences
03/12/2012 Experimental myasthenia gravis in Aire-deficient mice: a link between Aire and regulatory T cells Aricha, R. Annals of the New York Academy of Sciences
28/06/2012 Fatigue and muscle atrophy in a mouse model of myasthenia gravis is paralleled by loss of sarcolemmal nNOS. Meinen S PLoS One
01/10/2012 Human mesenchymal stem cells shift CD8+ T cells towards a suppressive phenotype by inducing tolerogenic monocytes. I.Hof Nahor Journal of Cell Science
29/10/2012 Implication of double-stranded RNA signaling in the etiology of autoimmune myasthenia gravis. Cufi P. Annals of Neurology
26/09/2011 Inflammation and Epstein-Barr virus infection are common features of myasthenia gravis thymus : possible roles in pathogenesis Cavalcante P Autoimmunity
31/05/2011 Mesenchymal stem cells as an immunomodulatory therapeutic strategy for autoimmune diseases Ben-Ami Eyal Autoimmune Review
30/04/2011 Muscle-selective synaptic disassembly and reorganization in MuSK antibody positive MG mice. Punga AR ; Rüegg MA Exp Neurol
24/01/2011 MuSK levels differ between adult skeletal muscles and influence postsynaptic plasticity. Punga AR ; Rüegg MA Eur J Neurosci
30/11/2010 Mutant SOD1 and mitochondrial damage alter expression and splicing of genes controlling neuritogenesis in models of neurodegeneration. Lenzken SC, Human Mutation
01/08/2010 Recent approaches to the development of antigen-specific immunotherapies for myasthenia gravis Lagoumintzis G Autoimmunity
23/05/2012 SDF-1/CXCL12 recruits B cells and antigen-presenting cells to the thymus of autoimmune myasthenia gravis patients. JM. Weiss Immunobiology
23/02/2012 Signaling and aging at the neuromuscular synapse: lessons learnt from neuromuscular diseases. Punga AR, Rüegg MA. Current Opinion in Pharmacology
31/08/2012 Smoking and socio-economic status may affect myasthenia gravis Maniaol AH Eur J Neurol.
31/07/2011 The p.Arg63Trp polymorphism controls Vav1 functions and Foxp3 regulatory T cells development. Colacios C, Casemayou A J. Exp. Med
28/02/2011 The susceptibility of Aire-/- mice to experimental myasthenia gravis involves alterations in regulatory T cells Aricha R Journal of Autoimmunity
03/10/2011 The thymus in myasthenia gravis : Siteof «innate autoimmunity » ? Cavalcante P Muscle and Nerve
17/08/2012 The timing of IFNb production affects early innate responses to Listeria monocytogenes and determines the overall outcome of lethal infection. Pontiroli F PLoS One
01/08/2010 Thymic remodeling associated with hyperplasia in myasthenia gravis Le Panse R Autoimmunity
17/12/2012 Treg cell-based immunotherapies in experimental autoimmune myasthenia gravis Souroujon, M.C. Annals of the New York Academy of Sciences